what sample rate are you using? and what is the buffer settings?
I found this online:
What's fantastic is that all monitor routing and reverb levels are software matrix — controlled, not hard-wired, so you can easily create blends between DAW output buses and live inputs for each performer, all with zero latency and zero impact on your CPU...
...With five separate stereo outs with DSP-based plug-ins on them, latency-free monitoring is child's play...
...The FireWire latency was impressively low at 4 ms in 44.1k operation, making Saffire an excellent choice for live, virtual instrument — based performances when tag-teamed with a laptop
Are we both talking about the same Focusrite Saffire?