Personally I'd go with a Marshall 1960 4x12 enclosure as that is as close to the industry standard as they come.
Live you can also request dual mic setup, considering you're the only guitarist in the band. If you're not it could pose problems as some of the smaller venues might not have the ability to mix more than one guitar channel per player. In that case I would find an engineer that can be trusted to pick the speaker to be used or you can run mic tests on each. I doubt that there will be that much difference between speakers, considering you'd have a lot of other factors influencing sound: difference in sound systems from venue to venue, mic brands and mic positioning.
Live sound is oftentimes plug and pray, especially when you rely on the venue's system and engineers.