A few software firms still state that it may be optimal to turn it off, but I suspect this is more in order to minimize potential support calls more than anything else. The last time I saw hyperthreading having a seriously negitive effect on a sequencer was probably back on the P4's and these days the difference in having it on and off can be as much as 50% or 60% performance increase, so well worth keeping it on.
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ScanProAudio & 3XS Audio Systems
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