Can anyone simply recommend the most reliable motherboard/ hard disk/ power supply etc. combo - I'm not taking any chances whatsoever this time.
I kinda expected people to come on here and defend Dells which is fair enough - still generally speaking if people are thinking about audio applications I would steer clear just in case.
I think theres a lot more to it that recommending a motherboard / hard disk etc... Theres a lot more to a build than just these things. The hard disk is really one of the least important things, along as you don't get a slow RPM (aim 7200-7600 at least).
Think of the important things first, processor, memory and sound card are probably your most important things to think about for power, then some kind of suitable sound proofing case would be good. You can find power supply etc to work around the important components.