But this is in recording also, not just live. I simply think you can hear the difference between physics of an amp and virtual reality (as would be expected, why wouldn't it be?) perhaps not so much with very uniform guitar amp tones like so many players seem to opt for, or droney playing, or heavily compressed/fuzzy amp sounds, but one thing seems to encourage the other.
Can you hear a difference on record between miked up amplifiers and modeling ? I can't with modern models, but clearly, the live sound experience is very different. In my (long ago) experience, when we supported top bands, we were at first surprised when there was a difference, when we had previously been trying to capture a "recorded" sound. Then we found that the difficulty with trying to capture a "live" sound was that we couldn't really tell how we sounded, so we just concentrated on trying to get the balance right on stage and hoped that the result translated well in the venue.
Nowadays, I simply aim for a decent sound coming out of the monitors.