Crackling noises in Cubase

Sorry if this goes on a bit, I’ll be as brief as I can. Pretty desperate here with a problem in Cubase.
I just upgraded to a new pc and am getting really bad crackling/spitting noises from my monitors.
My system:
Windows 10
Cubase 10.5
AMD Ryzen 9 3900X 12-Core Processor 3.90 GHz
WD SN550 1TB SSD
32G ram
MOTU 896mk3 Hybrid USB interface with MOTU8pre via ADAT
I’ve just come off working on an old Intel laptop which, although getting tired, worked fine with this setup. With the new AMD desktop system, I’m getting horrible noises from the speakers (which show on the MOTU meters but not within the Cubase session) when a session is idle and also some nasty glitching and degradation of audio during playback. When this occurs, cymbals for example sound like they have a flanging effect.
It first occurred when I changed the audio buffer size. Making this adjustment seems to make the problem flare up, regardless of whether I’m lowering or increasing the buffer setting.
Incidentally, the audio load meter in Cubase is never over half way and that’s only in sessions with many tracks and many instances of big plugins, such as Slate VTM. So, even in a tiny session of say, four tracks of drums, the problem still occurs. A brand new pc of this spec shouldn’t remotely break sweat with the work I’m attempting to do? There are no synths involved, it’s purely recorded audio and plugins.
I’m absolutely at a loss as to why this would occur. I am wondering if it’s perhaps related to the USB connection? On my old laptop system, I could only connect the MOTU USB2 cable via one specific USB port. On every other port, this same glitching would occur.
Now, I have tried connecting the MOTU to the PC via a a USB C converter box, to no avail. As I type this, the session I have open is idle but there is horrible crackling coming from my monitors.
I appreciate this may be a needle in a haystack but could anyone suggest where to start? I enquired on the Steinberg forum, where someone suggested using LatencyMon to assess the system? I have no idea how to use it though. Can anyone help?
I just upgraded to a new pc and am getting really bad crackling/spitting noises from my monitors.
My system:
Windows 10
Cubase 10.5
AMD Ryzen 9 3900X 12-Core Processor 3.90 GHz
WD SN550 1TB SSD
32G ram
MOTU 896mk3 Hybrid USB interface with MOTU8pre via ADAT
I’ve just come off working on an old Intel laptop which, although getting tired, worked fine with this setup. With the new AMD desktop system, I’m getting horrible noises from the speakers (which show on the MOTU meters but not within the Cubase session) when a session is idle and also some nasty glitching and degradation of audio during playback. When this occurs, cymbals for example sound like they have a flanging effect.
It first occurred when I changed the audio buffer size. Making this adjustment seems to make the problem flare up, regardless of whether I’m lowering or increasing the buffer setting.
Incidentally, the audio load meter in Cubase is never over half way and that’s only in sessions with many tracks and many instances of big plugins, such as Slate VTM. So, even in a tiny session of say, four tracks of drums, the problem still occurs. A brand new pc of this spec shouldn’t remotely break sweat with the work I’m attempting to do? There are no synths involved, it’s purely recorded audio and plugins.
I’m absolutely at a loss as to why this would occur. I am wondering if it’s perhaps related to the USB connection? On my old laptop system, I could only connect the MOTU USB2 cable via one specific USB port. On every other port, this same glitching would occur.
Now, I have tried connecting the MOTU to the PC via a a USB C converter box, to no avail. As I type this, the session I have open is idle but there is horrible crackling coming from my monitors.
I appreciate this may be a needle in a haystack but could anyone suggest where to start? I enquired on the Steinberg forum, where someone suggested using LatencyMon to assess the system? I have no idea how to use it though. Can anyone help?