From a personal PoV I can't get on with drop D without replacing the low E string with something slightly heavier to compensate for the reduction in tension. Consequently I have two guitars, one for standard tuning an one for drop D.
As for needing a set up as zen guitar says it depends. However I know plenty of guitarists who switch between standard tuning and drop D on the same guitar during the course of a set and you don't see any of them getting a set up between songs!
And when it come to the truss rod, I see far to many guitarists and bassists who are constantly fiddling with theirs after the slightest change in weather conditions. Personally the only times I have adjust the truss rod on any of my instruments is:
1. When a new (to me) instrument has arrived with completely wrong amount of relief for my taste.
2. When I have changed strings to ones with a very different tension.
3. When I have bought an instrument that has previously been in a part of the world with a very different climate to that of the UK.
Other than that I can live with the tiny changes in relief caused by the mild UK climate. If I lived somewhere more extreme I might have a different PoV.
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Do I need my guitar set up for drop D?
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You'll get more variation in tension by changing to a different brand of the same gauge strings, as you would just dropping the low E to a D.
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